Human Male Sex: Endocrine Disruption and Male Reproductive Wellness

Human Male Sex: Endocrine Disruption and Male Reproductive Wellness

9.1 Introduction

Male sexuality is set genetically at the time of fertilization because of the existence of the Y chromosome into the spermatozoan because it fuses using the X-chromosome-containing ovum, as well as the sex-determining region for the Y chromosome (SRY) then drives the bipotential gonad associated with the embryo in order to become a testis through hormone-independent mechanisms 1,2. But, when the testis that is early formed, growth of the total male phenotype, including further testicular development (masculinization), becomes totally influenced by a complex system of hormonal signals, especially hormones secreted through the testes 2. People who lack any gonads are phenotypically female 1 and endocrine intervention is necessary to change the default feminine phenotype to be male 2. This will make both development and upkeep of masculinization susceptible to endocrine-disrupting impacts after all developmental phases from very early embryo to adulthood; in specific, disruption of very very early embryonic developmental procedures might have consequences for male reproductive health in adult life 2. This chapter will deal with the results of endocrine interruption for development of the tract that is urogenital for sperm production.Continue reading